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Noninvasive Perfusion MRI in Alzheimer's Disease:A Preliminary Report Neurol 47:1339-1342, Sandson,T.A.,et al, 1996 See this aricle in Pubmed Article Abstract We performed functional MRI using the echo-planar imaging and signal targeting with alternating radio frequency(EPISTAR)technique in 11 11 patients with Alzheimer's disease(AD)and 8 age-matched control subjects. Seven of the AD patients had qualitatively apparent focal ares of hypoperfusion in the posterior temporoparietal-occipital regions.At the earliest inversion time producing cortical enhancement,the ratios of parieto-occipital and temporo-occipital to whole slice signal intensity were significantly lower in the AD patients than in the controls.Parieto- occipital hypoperfusion correlated with dementia severity as measured by the Blessed Dementia Scale.EPISTAR may prove to be a rapid,noninvasive alternative to other functional neuroimaging modalities in the evaluation of patients with dementia.

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